Medications that come in plastic capsules?
Make sure there is nothing about it on the bottle. My bottle of Dexilant says that I can open it. I stir it it in pudding and let it sit for several minutes. I'm not tough enough to just swallow them.
Otherwise, call a different pharmacist (you don't have to be their customer- just call one) and ask if a particular capsule (give the name) can be opened.