good news RNYers (and probably all WLS)
Br J Surg. 2012 Feb 2. doi: 10.1002/bjs.8693. [Epub ahead of print]
Effect of Roux-en-Y gastric bypass on testosterone and prostate-specific antigen.
Woodard G, Ahmed S, Podelski V, Hernandez-Boussard T, Presti J Jr, Morton JM.Source
Department of Surgery, Section of Minimally Invasive and Bariatric Surgery, California, USA.
Abstract
BACKGROUND:
Obese men have lower serum levels of testosterone, dehydroepiandrosterone (DHEA) and prostate-specific antigen (PSA), but an increased risk of dying from prostate cancer. The aim of this study was to examine the effect of surgically induced weight loss on serum testosterone, DHEA and PSA levels in obese men.
METHODS:
Consecutive men undergoing Roux-en-$\font\ss=cmss10 scaled 1000 \hbox{Y}$ gastric bypass (RYGB) participated in a prospective, longitudinal study. Main outcomes were changes were body mass index (BMI), percentage excess weight loss, serum levels of testosterone, DHEA and PSA, PSA mass and plasma volume, measured before operation and 3, 6 and 12 months later.
RESULTS:
In 64 patients, mean BMI fell from 48·2 kg/m(2) before operation to 39·2, 35·6 and 32·4 kg/m(2) at 3, 6 and 12 months after RYGB. Testosterone levels rose significantly from 259 ng/dl to 386, 452 and 520 ng/dl respectively. Serum PSA levels increased significantly from 0·51 ng/ml to 0·67 ng/ml at 12 months. There were no significant changes in DHEA or PSA mass.
CONCLUSION:
RYGB normalizes the serum testosterone level. PSA levels increase with weight loss and may be inversely correlated with changes in plasma volume, indicating that PSA levels may be artificially low in obese men owing to haemodilution. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
so what's this say?
That after the substantial loss of adipose tissue, a morbidly obese man should get much higher levels of man juice in the blood stream because adipose tissue helps convert testosterone to estrogen. So the better you get the easier is is to get better. Testosterone helps a lot with energy levels and shrength as well as supporting lean muscle mass.
Very good news!!
Second, that the PSA that pre-ops have may be diluted down by our great mass, and reducing the mass should make it go up A LITTLE (not a lot). This is something that should be discussed with your doc if a year later the psa went up some.
Trust their opinions.
I presently get testosterone shots every two weeks. My Endocrinologists ordered that I get shots because my readings were low due to diabetes.
Now, if I understood correctly, after WLS your numbers automatically go up ? That would mean, I would have to cut back on shots or stop getting them. If that's the case it would be of great benefit for us that take testosterone shots. My PSA reading are normal and so are all my other blood readings.
Today was my three month check-up with my cardiologist, all blood pressure reading were normal.
I shared with him the fact that I was having WLS, he said that as far as he was concern, I had the green light to go for it. I have to check back with him in three months to run some test and then he would approve me for surgery. Thank God, all the little ducks are lining up so far.
The weekend was great, my daughter sang in the church choir with all her classmates, these kids were fantastic, I think all of heaven was shouting with joy.
Wishing everyone the best week ever, Blessings.
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