Recent Posts
Topic: RE: stomache pain after eating/nausea 7yrs pos RNY
It seems not only do I have a lot of the same symtoms but several here as well. I wonder what has gon on with our bodies after the surgery and possible that the brain chemistry and signals have changed from what happened before.
I came across this the other day and think maybe the same thing can also happen after gastric bypass because of the instantaneous disrtuption in diet and foods eaten shocking the body and the brain whom has a hard time dealing with the sudden change and so goes into survivial mode.
A large academic study has demonstrated structural changes in specific brain regions in female patients with irritable bowel syndrome (IBS), a condition that causes pain and discomfort in the abdomen, along with diarrhea, constipation or both. A collaborative effort between UCLA and Canada's McGill University, the study appears in the July issue of the journal Gastroenterology. The findings show that IBS is associated with both decreases and increases in grey matter density in key areas of the brain involved in attention, emotion regulation, pain inhibition and the processing of visceral information. IBS affects approximately 15 percent of the U.S. population, primarily women. Currently, the condition is considered by the medical field to be a "functional" syndrome of the digestive tract not working properly rather than an "organic" disorder with structural organ changes. Efforts to identify structural or biochemical alterations in the gut have largely been unsuccessful. Even though the pathophysiology is not completely understood, it is generally agreed that IBS represents an alteration in brain-gut interactions. These study findings, however, show actual structural changes to the brain, which places IBS in the category of other pain disorders, such as lower back pain, temporomandibular joint disorder, migraines and hip pain — conditions in which some of the same anatomical brain changes have been observed, as well as other changes. A recent, smaller study suggested structural brain changes in IBS, but a larger definitive study hadn't been completed until now. "Discovering structural changes in the brain, whether they are primary or secondary to the gastrointestinal symptoms, demonstrates an 'organic' component to IBS and supports the concept of a brain-gut disorder," said study author Dr. Emeran Mayer, professor of medicine, physiology and psychiatry at the David Geffen School of Medicine at UCLA. "Also, the finding removes the idea once and for all that IBS symptoms are not real and are 'only psychological.' The findings will give us more insight into better understanding IBS." Researchers employed imaging techniques to examine and analyze brain anatomical differences between 55 female IBS patients and 48 female control subjects. Patients had moderate IBS severity, with disease duration from one to 34 years (average 11 years). The average age of the participants was 31. Investigators found both increases and decreases of brain grey matter in specific cortical brain regions. Even after accounting for additional factors such as anxiety and depression, researchers still discovered differences between IBS patients and control subjects in areas of the brain involved in cognitive and evaluative functions, including the prefrontal and posterior parietal cortices, and in the posterior insula, which represents the primary viscerosensory cortex receiving sensory information from the gastrointestinal tract. "The grey-matter changes in the posterior insula are particularly interesting since they may play a role in central pain amplification for IBS patients," said study author David A. Seminowicz, Ph.D., of the Alan Edwards Centre for Research on Pain at McGill University. "This particular finding may point to a specific brain difference or abnormality that plays a role in heightening pain signals that reach the brain from the gut." Decreases in grey matter in IBS patients occurred in several regions involved in attentional brain processes, which decide what the body should pay attention to. The thalamus and midbrain also showed reductions, including a region — the periaqueductal grey — that plays a major role in suppressing pain. "Reductions of grey matter in these key areas may demonstrate an inability of the brain to effectively inhibit pain responses," Seminowicz said. The observed decreases in brain grey matter were consistent across IBS patient sub-groups, such as those experiencing more diarrhea-like symptoms than constipation. "We noticed that the structural brain changes varied between patients who characterized their symptoms primarily as pain, rather than non-painful discomfort," said Mayer, director of the UCLA Center for Neurobiology of Stress. "In contrast, the length of time a patient has had IBS was not related to these structural brain changes." Mayer added that the next steps in the research will include exploring whether genes can be identified that are related to these structural brain changes. In addition, there is a need to increase the study sample size to address male-female differences and to determine if these brain changes are a cause or consequence of having IBS. The study was funded by the National Institutes of Health. Additional authors include M. Catherine Bushnell, Ph.D., of McGill University, and Jennifer B. Labus, Joshua A. Bueller, Kirsten Tillisch and Bruce D. Naliboff, Ph.D., all of UCLA. For more news, visit the UCLA Newsroom and follow us on Twitter.
http://newsroom.ucla.edu/portal/ucla/PRN-study-finds-structu ral-brain-alterations-156210.aspx
I came across this the other day and think maybe the same thing can also happen after gastric bypass because of the instantaneous disrtuption in diet and foods eaten shocking the body and the brain whom has a hard time dealing with the sudden change and so goes into survivial mode.
Study finds structural brain alterations in patients with irritable bowel syndrome
Findings suggest IBS similar to other pain disorders
By Rachel Champeau July 22, 2010A large academic study has demonstrated structural changes in specific brain regions in female patients with irritable bowel syndrome (IBS), a condition that causes pain and discomfort in the abdomen, along with diarrhea, constipation or both. A collaborative effort between UCLA and Canada's McGill University, the study appears in the July issue of the journal Gastroenterology. The findings show that IBS is associated with both decreases and increases in grey matter density in key areas of the brain involved in attention, emotion regulation, pain inhibition and the processing of visceral information. IBS affects approximately 15 percent of the U.S. population, primarily women. Currently, the condition is considered by the medical field to be a "functional" syndrome of the digestive tract not working properly rather than an "organic" disorder with structural organ changes. Efforts to identify structural or biochemical alterations in the gut have largely been unsuccessful. Even though the pathophysiology is not completely understood, it is generally agreed that IBS represents an alteration in brain-gut interactions. These study findings, however, show actual structural changes to the brain, which places IBS in the category of other pain disorders, such as lower back pain, temporomandibular joint disorder, migraines and hip pain — conditions in which some of the same anatomical brain changes have been observed, as well as other changes. A recent, smaller study suggested structural brain changes in IBS, but a larger definitive study hadn't been completed until now. "Discovering structural changes in the brain, whether they are primary or secondary to the gastrointestinal symptoms, demonstrates an 'organic' component to IBS and supports the concept of a brain-gut disorder," said study author Dr. Emeran Mayer, professor of medicine, physiology and psychiatry at the David Geffen School of Medicine at UCLA. "Also, the finding removes the idea once and for all that IBS symptoms are not real and are 'only psychological.' The findings will give us more insight into better understanding IBS." Researchers employed imaging techniques to examine and analyze brain anatomical differences between 55 female IBS patients and 48 female control subjects. Patients had moderate IBS severity, with disease duration from one to 34 years (average 11 years). The average age of the participants was 31. Investigators found both increases and decreases of brain grey matter in specific cortical brain regions. Even after accounting for additional factors such as anxiety and depression, researchers still discovered differences between IBS patients and control subjects in areas of the brain involved in cognitive and evaluative functions, including the prefrontal and posterior parietal cortices, and in the posterior insula, which represents the primary viscerosensory cortex receiving sensory information from the gastrointestinal tract. "The grey-matter changes in the posterior insula are particularly interesting since they may play a role in central pain amplification for IBS patients," said study author David A. Seminowicz, Ph.D., of the Alan Edwards Centre for Research on Pain at McGill University. "This particular finding may point to a specific brain difference or abnormality that plays a role in heightening pain signals that reach the brain from the gut." Decreases in grey matter in IBS patients occurred in several regions involved in attentional brain processes, which decide what the body should pay attention to. The thalamus and midbrain also showed reductions, including a region — the periaqueductal grey — that plays a major role in suppressing pain. "Reductions of grey matter in these key areas may demonstrate an inability of the brain to effectively inhibit pain responses," Seminowicz said. The observed decreases in brain grey matter were consistent across IBS patient sub-groups, such as those experiencing more diarrhea-like symptoms than constipation. "We noticed that the structural brain changes varied between patients who characterized their symptoms primarily as pain, rather than non-painful discomfort," said Mayer, director of the UCLA Center for Neurobiology of Stress. "In contrast, the length of time a patient has had IBS was not related to these structural brain changes." Mayer added that the next steps in the research will include exploring whether genes can be identified that are related to these structural brain changes. In addition, there is a need to increase the study sample size to address male-female differences and to determine if these brain changes are a cause or consequence of having IBS. The study was funded by the National Institutes of Health. Additional authors include M. Catherine Bushnell, Ph.D., of McGill University, and Jennifer B. Labus, Joshua A. Bueller, Kirsten Tillisch and Bruce D. Naliboff, Ph.D., all of UCLA. For more news, visit the UCLA Newsroom and follow us on Twitter.
http://newsroom.ucla.edu/portal/ucla/PRN-study-finds-structu ral-brain-alterations-156210.aspx
DS on 07/05/16
Topic: RE: So many problems advice needed
sorry that was to rbb825. and to dying inside im sorry you are having trouble hun.
DS on 07/05/16
Topic: RE: So many problems advice needed
![](https://images.obesityhelp.com/uploads/profile/916198/tickers/veronicaj5444a3df795aef5b2533e46d0cc41193d.png?_=6091604033)
i bet some of the nerve endings in your colon arent working uuhh it has a name and i know im gonna spell it completely wrong hurschbaums? my brother has it and had to have a colostomy bag put in but his became a really bad case
![](https://images.obesityhelp.com/uploads/profile/916198/tickers/veronicaj5444a3df795aef5b2533e46d0cc41193d.png?_=6091604033)
310/190/170
sw/cw/gw
"I don't cry over spilled milk because I'm lactose intolerant"
Topic: RE: Major Complications Almost 6 years-Chronic Nausea, vomiting, pain, severe deficiencies-less than 1%
anytime, I'm with you...end all suffering :)
Topic: RE: Major Complications Almost 6 years-Chronic Nausea, vomiting, pain, severe deficiencies-less than 1%
that is okjay with me. my email is [email protected]
i will look more at profile and maybe we both can chat sometime to compare when things were not right and to see if there is pattern somewhere that may not only help us but others as well
i will look more at profile and maybe we both can chat sometime to compare when things were not right and to see if there is pattern somewhere that may not only help us but others as well
Topic: RE: My Best Friend.....
How sad. A BMI of 54 and the other problems you mention contributed to your friend's risk of stroke, but I would agree that the surgery may have been a factor. However, each of us knew the risks going into this surgery, and decided that the chance of hope for a better future was worth the risk. I hope your grief softens with time and you have wonderful memories of your friend to sustain you.
Topic: RE: So many problems advice needed
Hi. I don't have your problem but I wanted to just say hello and wish you well. I am from Canton and work at the DMC, had my surgery at Harper but had lap band with Dr. Gazayerli. He is wonderful but of course Dr. Wood has a great reputation too. I hope you get some relief soon and that Dr. Wood can help.
Topic: RE: Major Complications Almost 6 years-Chronic Nausea, vomiting, pain, severe deficiencies-less than 1%
Hi,
I think you and I, and probably about 20 others I get emails from, ought to buy some lottery tickets if we are 1%...I think it may be more than that, but because of what you pointed out, that we all want to be successful and be a good example, I just think there are a lot of people that don't talk about the problems for fear of feeling left out, and a failure. I can only speak for myself, I feel like I don't "belong". Anyway, I just wanted to say that I am truly sad that you are this sick, and have been struggling this long, just unacceptable, believe me, I am still in the midst of it, and not sure if I am ever going to be right, I hope to at least be better than I am now. Please check out my blog, it is kind of lengthy, but I can only tell you how I feel, but as sad as I am when I read about someone else with these same issues, I am also struck with a kinship, and a feeling that I am not alone in this. I would like to add you as a friend, we can keep an eye on eachother :)
Hugs and prayers for your recovery
Jules
I think you and I, and probably about 20 others I get emails from, ought to buy some lottery tickets if we are 1%...I think it may be more than that, but because of what you pointed out, that we all want to be successful and be a good example, I just think there are a lot of people that don't talk about the problems for fear of feeling left out, and a failure. I can only speak for myself, I feel like I don't "belong". Anyway, I just wanted to say that I am truly sad that you are this sick, and have been struggling this long, just unacceptable, believe me, I am still in the midst of it, and not sure if I am ever going to be right, I hope to at least be better than I am now. Please check out my blog, it is kind of lengthy, but I can only tell you how I feel, but as sad as I am when I read about someone else with these same issues, I am also struck with a kinship, and a feeling that I am not alone in this. I would like to add you as a friend, we can keep an eye on eachother :)
Hugs and prayers for your recovery
Jules
Topic: RE: Severe abdominal pain
thanks for the reply. i have had 2 egd's and multiple ct scans. all normal. now throwing up almost everytime i eat and i'm scheduled for a hida scan tomorrow. i called my dr to let them know about the vomiting and abdominal pain, they told me there is nothing they can do until i get the hida scan. i was going to go to the er, but, i knew what would be done, so i sucked it up and stayed at home and dealt with it. i know something is not right, but what i don't know. my doctors just make me feel like it's all in my head. i'll be seeking a second opinion soon.
Topic: RE: Leg Edema and low protein
Talk to Dr about protein losing enteropathy. It can cause leg swelling, malnutrition, nausea, pain, vitamin deficiencies despote supplementation. One of the tests is a stool alpha 1 antitrysin where it measures to see if you have protein in stool which is not normal.
Also too endoscopy further down in small intestine with biopsies.
It is one of the things that is being looked into for me.
I have swelling in my legs but had diagnosis of lymphedema before surgery and is worse now in conjuction to numerous severe deficiencies, nausea, ect.
Albumin and prealbumin levels can be low because the protein is leaking from intestines. It is hard to find in some people the area and areas affected but there is treatment and help but to need to find specialist best at teaching hospital or if bariatric doc willing to look at possibility bring the link I included printed out to appt and ask him/her.
It could have been preexisting happened afterward or unknown.
I have been told in my case that reversal can make things worse and not recommended by doctor at stanford and recently at ucla. am getting workups done. just posted my story with follow ups
Here is link to read on it more.
http://emedicine.medscape.com/article/182565-overview
may need to sign up for free account. this is great place for other info too.
GL
Also too endoscopy further down in small intestine with biopsies.
It is one of the things that is being looked into for me.
I have swelling in my legs but had diagnosis of lymphedema before surgery and is worse now in conjuction to numerous severe deficiencies, nausea, ect.
Albumin and prealbumin levels can be low because the protein is leaking from intestines. It is hard to find in some people the area and areas affected but there is treatment and help but to need to find specialist best at teaching hospital or if bariatric doc willing to look at possibility bring the link I included printed out to appt and ask him/her.
It could have been preexisting happened afterward or unknown.
I have been told in my case that reversal can make things worse and not recommended by doctor at stanford and recently at ucla. am getting workups done. just posted my story with follow ups
Here is link to read on it more.
http://emedicine.medscape.com/article/182565-overview
may need to sign up for free account. this is great place for other info too.
GL