Question:
Why has my dosage dropped?

When I started on Coumadin and my dose stabalized I was alternating 10 and 12.5 mgs daily. This was in 1995 when I weighed 325. Then in 2005, at 500 pounds, I am still taking the same dose. Now, post op, my dose almost immediately needed to be reduced and am currently taking 5mgs daily. It obviously isn't weight related because I was much lighter taking a higher dose than I am now? Has anybody had this explained to them???    — David B. (posted on June 27, 2005)

June 26, 2005
Hey David, Coumadin is not a weight based drug It is titrated to a lab value called pt/inr. The dosage is then given according to the level of the pt/inr and what your md wants it at. Also your dietary needs play a part in the level. Avoid vit K because this is the antidote and will reverse your level too low. Also you have to be careful with green leafy vegs. I am sure you know your dietary restrictions. But understand it isn't based on how much you weigh. take care Deb 4/26/04 351/170
   — msdebbs

June 26, 2005
Thanks Deb...I understand all that although I forget about the leafy vegies sometimes. My only question is this...what has changed so drastically after surgery that affects the absorption of coumadin. Thanks again!
   — David B.

June 27, 2005
David, were you on any herprin or lovenox shots following surgery? for how long? those shots are blood thinners as well , if you were on them for a few weeks that could also explain why you does was lowered. it is determind by your blood levels (PT/PTT)how you doing otherwise? Tracey
   — traceybubbles