Did anyone have a hard time with prozac being effective after Surgery?

I am 6 months out and have been on prozac 40mg since 1997. For the past 3 weeks I have been so jumpy, easily set off, grouchy, and very critical of people. Does the pouch still absorb the anti depresant like it once did or does this change. Has anyone ever had to take the antidepresant more frequently daily?

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