Vitamin Tidbits of the Day
A bit of science for y'all:
Vitamin D is processed in the liver. Once vite D is transported to the liver, it undergoes the first of two hydroxylation steps at carbon 25 via the enzyme 25-hydroxylase to form 25-hydroxy-D.
25-Hydroxy-D3 is an inactive form of vite D that circulates in the blood before transport to the kidney where it undergoes a second hydroxylation at carbon 1, catalyzed by the enzyme 25-OH-D3-1 alpha-hydroxylase. The product 1,25-dihydroxyvitamin D is the active form of the vitamin necessary for bone mineralization, intestinal calcium uptake, and calcium mobilization.
So really, what does all this gibberish mean?
It means that your lab results for D could be one of three things:
1) 0,25-OH-D
2) 1,25-OH-D
3) 0,25-OH-D + 1,25-OH-D
We *only* care about the 0,25-OH-D as that is what is in reserves, not what is being actively used by your body at that moment in time.
Vitamin D is processed in the liver. Once vite D is transported to the liver, it undergoes the first of two hydroxylation steps at carbon 25 via the enzyme 25-hydroxylase to form 25-hydroxy-D.
25-Hydroxy-D3 is an inactive form of vite D that circulates in the blood before transport to the kidney where it undergoes a second hydroxylation at carbon 1, catalyzed by the enzyme 25-OH-D3-1 alpha-hydroxylase. The product 1,25-dihydroxyvitamin D is the active form of the vitamin necessary for bone mineralization, intestinal calcium uptake, and calcium mobilization.
So really, what does all this gibberish mean?
It means that your lab results for D could be one of three things:
1) 0,25-OH-D
2) 1,25-OH-D
3) 0,25-OH-D + 1,25-OH-D
We *only* care about the 0,25-OH-D as that is what is in reserves, not what is being actively used by your body at that moment in time.
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