Zinc and Calcium
Keep in mind I'm avidly searching for a print version of this study (published in 94, online archive**** at 97...) but here's an abstract from a study that is cited QUITE often:
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&orig in=ibids_references&therow=49559
The effect of calcium carbonate and calcium citrate on the absorption of zinc in healthy female subjects -- V. Argiratos, S. Sammam
Published in the European Journal of Clinical Nutrition, March 94
OBJECTIVES: The aim of this study was to determine the effect of calcium carbonate and calcium citrate on zinc absorption.
DESIGN: The zinc tolerance test (ZTT), which is the plasma zinc response to an oral zinc challenge, was used to quantitate zinc absorption. A physiological test dose of zinc (4.5 mg elemental zinc as 20 mg zinc sulphate) was used. Subjects underwent ZTTs on three separate occasions, each time consuming in random order, either 4.5 mg elemental zinc, zinc with 600 mg elemental calcium as calcium carbonate or zinc with 600 mg elemental calcium as calcium citrate.
SETTING: Metabolic ward conditions.
SUBJECTS: Nine, free-living, healthy female subjects recruited from the University population.
INTERVENTIONS: Blood samples were obtained at 30 min intervals for 4 h postdose.
RESULTS: The area under the plasma zinc curve (AUC) (mean +/- SEM) following the coingestion of zinc with calcium carbonate (438.4 +/- 129.0 mumol Zn.min/100 g albumin) and calcium citrate (308.0 +/- 110.5) was significantly lower (P less than 0.017) than when zinc was ingested alone (1561.7 +/- 240). Urinary excretion of calcium was significantly higher (P less than 0.017) at 4 h after supplementation with calcium citrate (0.83 +/- 0.12 mumol Ca/mumol creatinine) compared with calcium carbonate (0.40 +/- 0.11).
CONCLUSIONS: The decrease in zinc absorption following the ingestion of zinc with different forms of calcium suggests that an antagonistic competition occurred between the minerals and that elemental calcium is the inhibiting factor.
So don't ask me why they combine the two of them!
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&orig in=ibids_references&therow=49559
The effect of calcium carbonate and calcium citrate on the absorption of zinc in healthy female subjects -- V. Argiratos, S. Sammam
Published in the European Journal of Clinical Nutrition, March 94
OBJECTIVES: The aim of this study was to determine the effect of calcium carbonate and calcium citrate on zinc absorption.
DESIGN: The zinc tolerance test (ZTT), which is the plasma zinc response to an oral zinc challenge, was used to quantitate zinc absorption. A physiological test dose of zinc (4.5 mg elemental zinc as 20 mg zinc sulphate) was used. Subjects underwent ZTTs on three separate occasions, each time consuming in random order, either 4.5 mg elemental zinc, zinc with 600 mg elemental calcium as calcium carbonate or zinc with 600 mg elemental calcium as calcium citrate.
SETTING: Metabolic ward conditions.
SUBJECTS: Nine, free-living, healthy female subjects recruited from the University population.
INTERVENTIONS: Blood samples were obtained at 30 min intervals for 4 h postdose.
RESULTS: The area under the plasma zinc curve (AUC) (mean +/- SEM) following the coingestion of zinc with calcium carbonate (438.4 +/- 129.0 mumol Zn.min/100 g albumin) and calcium citrate (308.0 +/- 110.5) was significantly lower (P less than 0.017) than when zinc was ingested alone (1561.7 +/- 240). Urinary excretion of calcium was significantly higher (P less than 0.017) at 4 h after supplementation with calcium citrate (0.83 +/- 0.12 mumol Ca/mumol creatinine) compared with calcium carbonate (0.40 +/- 0.11).
CONCLUSIONS: The decrease in zinc absorption following the ingestion of zinc with different forms of calcium suggests that an antagonistic competition occurred between the minerals and that elemental calcium is the inhibiting factor.
So don't ask me why they combine the two of them!
Most Active
Recent Topics
